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Download Advances in Virus Research, Vol. 62 by Karl Maramorosch, Frederick A. Murphy, Aaron J. Shatkin PDF

By Karl Maramorosch, Frederick A. Murphy, Aaron J. Shatkin

The Advances in Virus study sequence covers a various diversity of in-depth experiences delivering a helpful assessment of the present box of virology. This eclectic quantity includes six reports masking subject matters with regards to plant viruses, evolution of viruses with hosts and mobilephone reputation by means of viruses. Six finished experiences on: * Varicella Virus - Mononuclear telephone interplay * Evolution of mobile attractiveness via Viruses: A resource of organic Novelty with scientific Implications * Infectious Pancreatic Necrosis Virus: Biology, Pathogenesis and Diagnostic tools * buildings of Picrona-like plant viruses: Implications and functions * Cucumoviruses * Co-Evolution of Viruses with Hosts and Vectors and attainable Paleontology

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A comparison of receptor interactions and entry pathways of different picornaviruses suggests that those receptors that bind into canyons or pits of the capsid induce partial capsid destabilization through displacement of the ‘‘pocket factor,’’ which contributes to capsid stability. This type of receptor-mediated destabilization occurs in poliovirus, some coxsackieviruses, and the 48 ERIC BARANOWSKI ET AL. major group rhinoviruses, which utilize molecules of the Ig superfamily as receptors. ). Examples include the binding of VLDV receptor to the five-fold axis region of the minor group of HRV-2, echovirus 7 binding to DAF and FMDV binding to integrins or other receptor molecules (Table III).

Intracellular mature virus and extracellular enveloped virus are two antigenically and structurally distinct infectious virions that bind to unidentified and possibly different cellular receptors (Vanderplasschen and Smith, 1997). Other examples of the use of several receptor types by a virus include adenoviruses, coronaviruses, hepatitis C virus, influenza virus, measles virus, and rabies virus (references and additional examples in Table III and Section IV). B. , 1976). , 2001). , 1997). These viruses belong to immeasurably distant families and are associated with unrelated diseases.

EVOLUTION OF CELL RECOGNITION BY VIRUSES 25 TABLE I BIOLOGICAL RELEVANCE OF QUASISPECIES DYNAMICS FOR RNA VIRUSESa Relevant parameters 1. Average number of mutations per genome found in a viral population: typically it ranges from 1 to 100 2. Virus population size: very variable but can reach 109 to 1012 in some infections in vivo 3. Genome length: 3 to 33 kb, with compact genetic information 4. Mutations needed for a phenotypic change: one or few mutations, as documented amply in the text for changes in receptor recognition specificity Examples of phenotypic changes in RNA viruses dependent on one or few mutations 1.

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