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By Ashaunta T. Anderson

50 reports each Pediatrician may still comprehend presents key reviews that experience formed the present medical perform of pediatrics. chosen utilizing a rigorous technique, the experiences disguise subject matters together with: hypersensitivity immunology, behavioral, cardiology, dermatology, endocrinology, ENT, basic pediatrics, hematology, infectious sickness, neonatology, nephrology, neurology, oncology, ophthalmology, orthopedics, and pulmonary. for every examine, a concise precis is gifted with an emphasis at the effects and barriers of the learn, and its implications for perform. An illustrative scientific case concludes every one evaluation, by means of short details on different proper reviews. this can be one of many simply books of its style to offer a suite of the main influential medical trials in pediatrics which are unique sufficient for use on rounds, yet nonetheless simply digestible.

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How Many Patients: 6 36 Ca r diology Study Overview: A case series of 6 consecutive infants treated with indomethacin who otherwise would have had surgical PDA ligation. 5 mg/​kg by NG tube. Follow-​Up: Patients were followed up by physical exam and echocardiographic evaluation at 3, 6, 12, and 24 hours, and then daily. Endpoints: • Clinical signs of severe left-​to-​r ight shunting including bounding pulses, hyperactive precordium, cardiomegaly, and systolic murmur • Progressive pulmonary edema on chest x-​ray • Left atrial/​aortic root (LA/​Ao) ratio, a marker of left-​to-​r ight shunting RESULTS • Five of 6 infants had complete resolution of clinical findings of PDA.

1989;320(23):1511–​1516. 6. Noori S, Mccoy M, Friedlich P, et a l. Failure of ductus arteriosus closure is associated with increased mortality in preterm infants. Pediatrics. 2009;123(1):e138–​e144. 7. Benitz WE. Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis? J Perinatol. 2010;30(4):241–​252. Schmidt B, Davis P, Moddemann D, et al. Long-​term effects of indomethacin prophylaxis in extremely-​ low-​ birth-​ weight infants. N Engl J Med. 2001;344(26):1966–​1972.

12 B e h a v i o ra l Who Was Excluded: Children with tuberous sclerosis, Angelman syndrome, fragile X syndrome, and congenital rubella—​a ll of which are associated with autism. Children who emigrated or who died were also excluded. How Many Patients: 537,303 children, 82% of whom received the MMR vaccine and 18% of whom did not. 1). 1 Summary of the Study’s Design. The authors used data from the Danish National Board of Health to determine which children received the MMR vaccine as well as the age of vaccine administration.

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